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Parts utilized

Chemical constituents and properties
Leaves contain a high percentage of potassium salts (0.7 gm in 100 grams of fresh leaves.
From dried leaves, a small amount of volatile oil and a bitter alkaloid, orthosiphonin.
Considered anti-allergic, anti-inflammatory, anti-bacterial and hypoglycemic.

Decoction of leaves used for kidney and bladder problems and other afflictions of the urinary tract.
Also used for its diuretic effect.
Poultice of leaves or chewed leaves stuffed onto painful tooth.
Java Tea is derived from Orthosiphon aristatus, touted for its diuretic action, kidney flushing benefits for kidney and bladder stones.

Antihypertensive: Antihypertensive actions of methylripariochromene A from Orthosiphon aristatus, an indonesian traditional medicinal plant : Methylripariochromene A (MRC), isolated from the leaves of OA showed blood pressure lowering effect and a vasodilating action, decrease cardiac output and diuretic action. It supports the traditional use of the plant for hypertension treatment.
Na+,K+-ATPase Inhibition: In the study of ten Thai indigenous medicinal plants, O aristatus showed high potent inhibitory activity .
Three Indonesian medicinal plants were studied for their biologically active constituents. Three benzochromenes and four isopimarane-type diterpenes isolated from the leaves of Orthoshiphon aristatus were shown to exhibit inhibitory effects on
smooth muscle contractions caused by several stimulants
Diuretic: O. stamineus extract exhibited dose-dependent diuretic activity with a significantly increased excretion of K. There was also slight increase of BUN, creatinine and blood glucose levels, although statistically significant when compared to control , the levels were considered within normal range. Although less potent than furosemide and HCTZ, care should be taken in its consumption because of alterations in kidney parameters.
Nephrolitihiasis Study : In a randomized control trial of Orthosiphon versus placebo, no statistically significant difference was found.
Hepatoprotective : A study on the methanol extract of leaves of Orthosiphon staminues against paracetamol-induced hepatotoxicity showed treatment with OS extract brought back the alterered biochemical markers in a dose-dependent manner suggesting hepatoprotective activity.
Diuretic / Hypouricemic : A study on the methanol extract of OS showed significantly increased excretion of sodium and potassium excretion in a pattern comparable to hydrochlorothiazide. It also showed reduced serum urate level in hyperuricemic rats. Study provides evidence towards a diuretic and hypouricemic effect in rats.

Toxicity Study
Chronic Toxicity Test : A study on the chronic toxicity of water extract of Orthosiphon aristatus on Wistar rats showed that high doses of the extract caused a reduction of serum sodium levels in all extract-treated groups and increase alklaine phosphatase level and incidence of hydrocalyx in male rats, therefore advising that the prolonged use of OA should be avoided.


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