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Parts used
Young leaves and stems
Chemical constituents and properties
• Considered purgative, anthelmintic, antidiabetic.
Uses
Nutritional
Young leaves and shoots eaten raw in salads, or steam and boilded like spinach.
Young stems popular as achara (native pickles) ingredient.
Good sources of iron, calcium, vitamins B and C and amino acids.
Folkloric
Tops are mildly laxative.
The purplish variety used for diabetes because of assumed insulin-like principle it contains.
Juice used as emetic.
Dried latex is purgative.
Poultice of buds used for ringworm.
In Ayurveda, exgtracts of leaves are used for jaundice and nervous debility.
Juice used as emetic in opium and arsenic poisoning.
In Sri Lanka, used for liver disease, eye problems, constipation.
Studies
• Hypoglycemic / Anti-Diabetic: (1) Study showed the boiled whole extract of I. aquatica to exert an oral hypoglycemic effect in healthy, male, Wistar rats after a glucose challenge. (2) An aqueous extract of the green leafy vegetable Ipomoea aquatica is as effective as the oral hypoglycaemic drug tolbutamide in reducing the blood sugar levels of Wistar rats.(3) Inhibitory effect of Ipomoea aquatica extracts on glucose absorption using a perfused rat intestinal preparation: Study showed a significant inhibitory effect on glucose absorption. Furthermore, results suggest the inhibition of glucose absorption is not due to the acceleration of intestinal transit. (3) Study showed the consumption of shredded, fresh, edible portion of IA for one week, effectively reduced the fasting blood sugar of Streptozotocin-induced diabetic rats.
• Antioxidant / Antiproliferative: Antioxidant and antiproliferative activities of water spinach (Ipomoea aquatica Forsk) constituents: Study showed the water extract of stems had the highest antiproliferative activity. The ethanol extract of the stems had the highest total phenolic compounds. The ethanol extract of leafves had the highest amount of flavonoids.
• Diuretic: Study on the diuretic activity of the methanol extract of Ipomoea aquatica in Swiss albino mice showed good diuretic activty. In all cases, the excretion of electrolytes and urine volue increase was higher than the standard diuretic, furosemide.
• Antioxidant: Study of a methanol extract yielded a compound ( 7-O-B-D-glucopyronosyl-dihydromquercetin-3-O-a-D-glucopyranoside) that exhibited antioxidant activity with an EC50 value of 83 and showed very strong lipid peroxidation-inhibitory activirty in a liposome model system.
Chemical constituents
Rich in tannin: fruit, 14 to 17 %; leaves 13 %; bark, 10%.
Corrosolic acid is being studied for its glucose lowering effect.
Parts utilized
Leaves, fruits, flowers and bark.
Uses
Folkloric
– Roots have been used for a variety of stomach ailments. Leaf decoction for diabetes; also use as a diuretic and purgative.
– Decoction of old leaves and dried fruit (dried from one to two weeks), 50 gms to a pint of boiling water, 4 to 6 cups daily has been used for diabetes. Old leaves and ripe fruit are preferred, believed to have greater glucose lowering effect. Young leaves and flowers have a similar effect, though only 70% that of matures leaves and fruits. The wood has no known glucose lowering effect; the bark, a very small amount. A decoction of 20 gms of old leaves or dried fruit in 100 cc of water was found to have the equivalent effect to that of 6 to 7.7 units of insulin.
– The bark decoction has been used for the treatment of diarrhea.
– The bark, flowers and leaves used to facilitiate bowel movements.
– Decoction of fruits or roots gargled for aphthous stomatitis.
– Decoction of leaves and flowers used for fevers and as diuretic.
– Leaf decoction or infusion used for bladder and kidney inflammation, dysuria, and other urinary dysfunctions.
Studies
• Diabetes: (1) Banaba is being studied for its application in the treatment of diabetes. Its ability to lower blood sugar is attributed to its corosolic acid, a triterpenoid glycoside, belived to facilitate glucose-transport into cells. (2) Studied with abutra, akapulko, makabuhay for antidiabetic activity through activation of gucose transporter activity. One of the active principles from Banaba was the tripertene, corosoric aicd.
• Weight loss: Studies in mice suggest an antiobesity effect. It is becoming a common ingredient in weight-loss supplements / products as a metabolic enhancer.
• Hypertension: It is also being studied for its use in the treatment of blood pressure, renal and immune system benefits. • Lipid-lowering: Studies in mice suggest a lipid lowering effect – decreasing triglyceride and total cholesterol levels. To date, no toxicity has been identified.
• Hypoglycemic Activity of Irradiated Banaba Leaves: Study showed the effects of nBLE and iBLE were comparable to the hypoglycemic effects of insulin.
• Xanthine oxidase inhibitors from the leaves of Lagerstroemia speciosa (L.) Pers: Xanthine oxidase is a key enzyme involved with hyperuricemia, catalyzing the oxidation of hypoxanthine to xanthine to uric aicd. The study supports the dietary use of the aqueous extracts from Banaba leaves for the prevention and treatment of hyperuricemia.
• Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics a dose-dependence study: Study showed a significant reduction of blood glucose levels with the soft gel formulation showing better bioavailability than a dry-powder formulation.
Source: http://www.stuartxchange.org/Banaba.html
Other useful sites:
Chemical constituents and properties
• From the seed is produced a bitter fixed oil, nimbidin, known as “Oil of Margosa” or neem oil.
• Neem seeds yield a fix oil of glycerides and bitter compounds including nimbin, nimbinin and nimbidol.
• Neem bark and leaves contain tannin and oil.
• Azadirachtin, the insecticide constitutent of the seeds, is biodegradable, non-mutagenic, and nontoxic to birds, fish, and warm-blooded animals. The EPA has approved a neem formulation (Margosan-O) as a pesticide for limited use on nonfood crops
• Antiinflammatory (nimbidin, sodium nimbidate, gallic acid, catechin, polysachharides).
• Antiarthritic, hypoglycemic, antipyretic, hypoglycemic, diuretic, anti-gastric ulcer (nimbidin)
• Antifungal (nimbidin, gedunin, cyclic trisulfide)
• Antibacterial (nimbidin, nimbolide, mahmoodin, margolone, margolonone, isomargolonone)
• Spermicidal (nimbin, nimbidin)
• Antimalarial (nimbolidfe, gedunin, azadirachtin)
• Antitumor (polysaccharides)
• Immunomodulatory (NB-II peptoglycan, gallic acid, epicatechin, catechin)
• Hepatoprotective (aequeous extract of neem leaf)
• Antioxidant (neem seed extract)
Parts used and preparation
Whole plant.
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Uses
Folkloric
Poultice of leaves for swollen glands, brusies and sprains.
Fresh leaf-tea used for malaria.
Tree and root barks have been used for malaria, jaundice, and for intestinal parasitism.
Edible pulp of the fruit used for hemorrhoids.
Ayurvedic medicine
Leaf- leprosy, intestinal parasites, eye problems, skin ulcers
Bark – pain and fever.
Flower – bile suppression, intestinal worms and phlegm.
Fruit – piles, intestinal worms, urinary disorder, nose bleeding , phlegm, eye problem, diabetes, wounds and leprosy.
Twig – cough, asthma, piles, intestinal worms, spermatorrhoea, urinary disorders, diabetes.
Gum – ringworms,scabies, wounds and ulcers.
Seed pulp and oil- leprosy and intestinal worms.
Others
Young tender branches are chewed for toothbrushing use.
Leaf’s oil is used as a local antiseptic and insecticide.
Neem oil may be useful for gingivitis.
In the rural areas, burning of leaves and seeds used as mosquito repellant.
Neem oil has been shown to possess some spermicidal and contraceptive properties when used intravaginally.
Use of neem oil in animals showed lowering of glucose
Commercial use
Neem extracts used in the manufacture of toothpaste for its antibacterial properties.
Fresh seed oil has a strong garlic odor and is an ingredient for insect sprays.
Studies
• Studies have suggested hypoglycemic, antiulcer, antifertility, antimalarial, antifungal, antibacterial, antiviral, anticancer and antioxidant effects.
• Effect of essential oils from two Nigerian medicinal plants (Azadirachta indica and Morinda lucida) on growth and aflatoxin B1 production in maize grain by a toxigenic Aspergillus flavus: Oils from A indica completely suppressed aflatoxin synthesis.
• Lipid Effects / Antiviral: Effect of Supplemental Garlic and Neem Leaves in Broiler Feeds on Blood Cholesterol, Triglycerids and Antibody Titer: Study showed neem had greater potential than garlic in reducing cholesterol, triglycerides and increasing the antibody titers against viruses.
• Anti-ulcer: Mechanism of antiulcer effect of Neem (Azadirachta indica) leaf extract: effect on H+-K+-ATPase, oxidative damage and apoptosis: Study suggests antiulcer activity is achieved by blocking acid secretionn through inhibition of H+K+ATPase and preventing oxidative damage and apoptosis.
• Anti-candidal: Anticandidal activity of Azadirachta indica: Study suggested hexane and alcoholic extracts to have anticandidal potential.
Source: http://www.stuartxchange.org/Neem.html
Related Sites:
http://www.discoverneem.com/neem-benefits.html
http://www.articlealley.com/article_766808_17.html
http://herbal-properties.suite101.com/article.cfm/research_supports_value_of_neem_herbal_extracts
http://www.healthypages.co.uk/newsitem.php?news=6070
http://www.americanchronicle.com/articles/view/42953
http://www.goherbalremedies.com/blog/herbal-remedies-by-neem-leaves-margosa/
http://www.neemfoundation.org/neem-articles/neem-in-health.html