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By David Morgan – Wed Sep 23, 2:16 PM PDT
WASHINGTON (Reuters) – A diet high in a form of sugar found in sweetened soft drinks and junk food raises blood pressure among men, according to research likely to mean more bad news for beverage companies and restaurant chains.
One of two studies released on Wednesday provided the first evidence that fructose helps raise blood pressure. It also found that the drug allopurinol, used to treat gout, can alleviate the effect by reducing uric acid levels in the body.
The second study, which measured fructose intake in mice, suggested that people who consume junk foods and sweetened soft drinks at night could gain weight faster than those who don’t.
“These results suggest that excessive fructose intake may have a role in the worldwide epidemic of obesity and diabetes,” said Dr. Richard Johnson of the University of Colorado-Denver, who studied the link between blood pressure and men.
The findings provide the latest evidence of ties between sugar-rich diets and health problems that have prompted some experts to call for a tax on sugary soft drinks.
Fructose accounts for about half the sugar molecules in table sugar and in high-fructose corn syrup, the sweetener used in many packaged foods.
Johnson and colleagues at the Mateo Orfila Hospital in Spain studied 74 men given 200 grams of fructose per day on top of their regular diet. That amount is well above a daily intake of 50 grams to 70 grams of fructose consumed by most American adults.
Half the men were also given allopurinol.
After two weeks, the men who received only the fructose registered increases of six millimeters in systolic blood pressure — the top reading — and about three millimeters in diastolic or the bottom reading, the researchers told an American Heart Association meeting in Chicago.
REVERSIBLE EFFECT
Most of their blood pressure readings returned to normal levels after two months.
The men who did not get allopurinol also were twice as likely to develop metabolic syndrome, measured by risk factors such as too much abdominal fat, high blood pressure and poor cholesterol readings.
By contrast, those given allopurinol and fructose had significantly lower uric acid levels, and virtually no increase in systolic blood pressure or higher risk of metabolic syndrome.
For the second study, researchers in Ohio studied mice given fructose water to drink. Some had unrestricted access, while others received it during the day or at night.
“The first thing we noticed was that the mice on restricted access rushed to their drinking bottles to load up on the sweetened beverage, similar to teenagers who drink too many soft drinks,” said Mariana Morris of Wright State University in Dayton, Ohio.
The mice that drank fructose water during their regular daylight sleeping hours gained more weight and had higher stress hormone levels than the other mice.
“This model may be similar to the human condition of night time bingeing of fructose-laden foods and beverages,” Morris said.
The American Heart Association says women should eat no more than 100 calories of added processed sugar per day, or six teaspoons (25 grams), while most men should keep it to just 150 calories or nine teaspoons (37.5 grams). On average Americans consume 22 teaspoons (90 grams) or 355 calories of added sugar each day.
(Editing by Maggie Fox and Xavier Briand)
Parts utilized
Leaves.
Chemical constituents and properties
Leaves contain a high percentage of potassium salts (0.7 gm in 100 grams of fresh leaves.
From dried leaves, a small amount of volatile oil and a bitter alkaloid, orthosiphonin.
Considered anti-allergic, anti-inflammatory, anti-bacterial and hypoglycemic.
Uses
Folkloric
Decoction of leaves used for kidney and bladder problems and other afflictions of the urinary tract.
Also used for its diuretic effect.
Poultice of leaves or chewed leaves stuffed onto painful tooth.
Others
Java Tea is derived from Orthosiphon aristatus, touted for its diuretic action, kidney flushing benefits for kidney and bladder stones.
Studies
• Antihypertensive: Antihypertensive actions of methylripariochromene A from Orthosiphon aristatus, an indonesian traditional medicinal plant : Methylripariochromene A (MRC), isolated from the leaves of OA showed blood pressure lowering effect and a vasodilating action, decrease cardiac output and diuretic action. It supports the traditional use of the plant for hypertension treatment.
• Na+,K+-ATPase Inhibition: In the study of ten Thai indigenous medicinal plants, O aristatus showed high potent inhibitory activity .
• Three Indonesian medicinal plants were studied for their biologically active constituents. Three benzochromenes and four isopimarane-type diterpenes isolated from the leaves of Orthoshiphon aristatus were shown to exhibit inhibitory effects on
smooth muscle contractions caused by several stimulants
• Diuretic: O. stamineus extract exhibited dose-dependent diuretic activity with a significantly increased excretion of K. There was also slight increase of BUN, creatinine and blood glucose levels, although statistically significant when compared to control , the levels were considered within normal range. Although less potent than furosemide and HCTZ, care should be taken in its consumption because of alterations in kidney parameters.
• Nephrolitihiasis Study : In a randomized control trial of Orthosiphon versus placebo, no statistically significant difference was found.
• Hepatoprotective : A study on the methanol extract of leaves of Orthosiphon staminues against paracetamol-induced hepatotoxicity showed treatment with OS extract brought back the alterered biochemical markers in a dose-dependent manner suggesting hepatoprotective activity.
• Diuretic / Hypouricemic : A study on the methanol extract of OS showed significantly increased excretion of sodium and potassium excretion in a pattern comparable to hydrochlorothiazide. It also showed reduced serum urate level in hyperuricemic rats. Study provides evidence towards a diuretic and hypouricemic effect in rats.
Toxicity Study
• Chronic Toxicity Test : A study on the chronic toxicity of water extract of Orthosiphon aristatus on Wistar rats showed that high doses of the extract caused a reduction of serum sodium levels in all extract-treated groups and increase alklaine phosphatase level and incidence of hydrocalyx in male rats, therefore advising that the prolonged use of OA should be avoided.