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Parts used
Young leaves and stems
Chemical constituents and properties
• Considered purgative, anthelmintic, antidiabetic.
Uses
Nutritional
Young leaves and shoots eaten raw in salads, or steam and boilded like spinach.
Young stems popular as achara (native pickles) ingredient.
Good sources of iron, calcium, vitamins B and C and amino acids.
Folkloric
Tops are mildly laxative.
The purplish variety used for diabetes because of assumed insulin-like principle it contains.
Juice used as emetic.
Dried latex is purgative.
Poultice of buds used for ringworm.
In Ayurveda, exgtracts of leaves are used for jaundice and nervous debility.
Juice used as emetic in opium and arsenic poisoning.
In Sri Lanka, used for liver disease, eye problems, constipation.
Studies
• Hypoglycemic / Anti-Diabetic: (1) Study showed the boiled whole extract of I. aquatica to exert an oral hypoglycemic effect in healthy, male, Wistar rats after a glucose challenge. (2) An aqueous extract of the green leafy vegetable Ipomoea aquatica is as effective as the oral hypoglycaemic drug tolbutamide in reducing the blood sugar levels of Wistar rats.(3) Inhibitory effect of Ipomoea aquatica extracts on glucose absorption using a perfused rat intestinal preparation: Study showed a significant inhibitory effect on glucose absorption. Furthermore, results suggest the inhibition of glucose absorption is not due to the acceleration of intestinal transit. (3) Study showed the consumption of shredded, fresh, edible portion of IA for one week, effectively reduced the fasting blood sugar of Streptozotocin-induced diabetic rats.
• Antioxidant / Antiproliferative: Antioxidant and antiproliferative activities of water spinach (Ipomoea aquatica Forsk) constituents: Study showed the water extract of stems had the highest antiproliferative activity. The ethanol extract of the stems had the highest total phenolic compounds. The ethanol extract of leafves had the highest amount of flavonoids.
• Diuretic: Study on the diuretic activity of the methanol extract of Ipomoea aquatica in Swiss albino mice showed good diuretic activty. In all cases, the excretion of electrolytes and urine volue increase was higher than the standard diuretic, furosemide.
• Antioxidant: Study of a methanol extract yielded a compound ( 7-O-B-D-glucopyronosyl-dihydromquercetin-3-O-a-D-glucopyranoside) that exhibited antioxidant activity with an EC50 value of 83 and showed very strong lipid peroxidation-inhibitory activirty in a liposome model system.
Chemical constituents and properties
• The dried leaves contain 0.21–1% essential oil, the major compounds of which are linalool and methyclaviol.
• Some of the other compounds are: caffeic acid, p-coumaric acid, p-cymene, limonene, 1,8-cineole, methyl cinnamate, myrcene, quercetin, rutin, tryptophan, safrole.
• Study yielded 14 different anthocyanins: 11 cyanidin-based pigments and 3 peonidin-based pigments.
• Carminative, stimulant, diaphoretic, expectorant, febrifuge, diuretic, demulcent, mucilaginous, cooling.
Parts utilized
Leaves, seeds.
Mature fresh leaves are harvested 2 to 3 months after planting. Leaves are picked leaving the branches on the plant to allow it to flower and produce seeds for the next season.
The leaves are air-dried until they crumble when crushed with the fingers. Store in amber colored bottles in a cool, dry place.
Uses
Culinary
The leafy and flowering tops are used as condiment; eaten sparingly in salads.
Folkloric
Cough: Expectorant properties – Take infusion or decoction of herb (9-15 gm of dried herb) or tops as tea.
Leaf juice helpful for expectoration of mucus.
Decoction of leaves also used for hiccups, vomiting and nausea.
Gas pains: Decoction of herb as tea helps to expel wind from bowels.
Snake bites: Crush fresh plant and poultice the bitten wound.
Gonorrhea, using a decoction of the roots and leaves of plants.
Decoction of leaves used as a wash for ulcers.
External contusions.
Used in baths for rheumatic pains.
Ringworm and insect bites: Apply juice of crushed leaves.
Skin ulcers: Decoction of herb as wash.
For delayed menstruation: take the juice of the leaves with water.
Seeds are used in treatment of several eye diseases.
Toothache: Wet small piece of cotton with juice of crushed leaves and insert into tooth cavity.
Postpartum: Decoction of seeds used to decrease postpartum pains; the seeds are mucilaginous.
Poultice of seeds used for buccal sores.
Decoction of seeds also used for constipation.
Acne: Infusion of 3 tsp of dried leaves in 1 cup of boiling water for 20-30 minutes. Apply externally or drink decoction of tea or infusion 3 times daily.
Others
• Oils repel insects (limonene, myrcene, camphor, thymol) and have larvicidal (eugenol and methylclaviol) activity against houseflies and mosquitoes.
Recent uses
Dizziness: crush enough fresh leaves with your fingers and sniff them.
Cough: As decoction boil eight tablespoons of fresh leaves in two glasses of water for 15 minutes or until the liquid is reduced to half. Divide the decoction into eight parts and take one part, three times a day.
Studies
• Aqueous extracts of Ocimum basilicum L. (sweet basil) decrease platelet aggregation induced by ADP and thrombin in vitro and rats arterio–venous shunt thrombosis in vivo: Results showed Ocimum basilicum to possess an inhibitory effect on platelet aggregation induced by ADP and thrombin resulting in an anti-thrombotic effect in vivo.
• Cardiac stimulant activity of Ocimum basilicum Linn. extracts: The study evaluated the cardiac effects of extracts derived from the aerial parts of Ocimum basilicum. Results showed the alcoholic extracts exhibited a cardiotonic effect and the aqueous extract produced a B-adrenergic effect.
• Antimicrobial Effects of Ocimum basilicum (Labiatae) Extract: Results suggest that O. basilicum extracts possess compounds with antimicrobial properties against C. albicans and some bacterial pathogens.
• Anti-dyspepsia: A Double-Blind Placebo-Controlled study showed Ocimum basilicum seems to relieve functional dyspepsia in female and young patients with dysmotility.
• Anthocyanins in Basil : Purple basils are an abundant source of acylated and glycosylated anthocyanins, a potential source of stable red pigments to the food industry.
• Antioxidant: In a study of plants in the Lamiaceae family, the leaves and stems of Ocimum basilicum displayed the highest antioxidant activity.
• Antiulcer: Study showed the seed extracts of OB to possess significant anti-ulcer activity against ethanol-induced ulceration in animal models.
• Wound-Healing Activity: Wounds treated with honey in combination with OB alcoholic leaf extract and solcoseryl-jelly showed accelerated wound healing compared to honey alone.
• Antiproliferative / Anticancer: A study on the antiproliferative activity of essential oil from 17 thai medicinal plants on human mouth epidermal carcioma (KB) and murine leukemia (P388) cell lines. In the KB cell line, Sweet Basil (Ocimum basilicum) oil showed the highest anti-proliferative activity in the P388 cell line. The results suggested the potential of Thai medicinal plants for cancer treatment.
Toxicity
Although known for its medicinal benefits, it contains some potentially dangerous compounds: safrole, rutin, caffeic acid, tryptophan and quercetin.(See: Medicinal Plants for Livestock / Cornell University)
Chemical constituents and properties
• From the seed is produced a bitter fixed oil, nimbidin, known as “Oil of Margosa” or neem oil.
• Neem seeds yield a fix oil of glycerides and bitter compounds including nimbin, nimbinin and nimbidol.
• Neem bark and leaves contain tannin and oil.
• Azadirachtin, the insecticide constitutent of the seeds, is biodegradable, non-mutagenic, and nontoxic to birds, fish, and warm-blooded animals. The EPA has approved a neem formulation (Margosan-O) as a pesticide for limited use on nonfood crops
• Antiinflammatory (nimbidin, sodium nimbidate, gallic acid, catechin, polysachharides).
• Antiarthritic, hypoglycemic, antipyretic, hypoglycemic, diuretic, anti-gastric ulcer (nimbidin)
• Antifungal (nimbidin, gedunin, cyclic trisulfide)
• Antibacterial (nimbidin, nimbolide, mahmoodin, margolone, margolonone, isomargolonone)
• Spermicidal (nimbin, nimbidin)
• Antimalarial (nimbolidfe, gedunin, azadirachtin)
• Antitumor (polysaccharides)
• Immunomodulatory (NB-II peptoglycan, gallic acid, epicatechin, catechin)
• Hepatoprotective (aequeous extract of neem leaf)
• Antioxidant (neem seed extract)
Parts used and preparation
Whole plant.
.
Uses
Folkloric
Poultice of leaves for swollen glands, brusies and sprains.
Fresh leaf-tea used for malaria.
Tree and root barks have been used for malaria, jaundice, and for intestinal parasitism.
Edible pulp of the fruit used for hemorrhoids.
Ayurvedic medicine
Leaf- leprosy, intestinal parasites, eye problems, skin ulcers
Bark – pain and fever.
Flower – bile suppression, intestinal worms and phlegm.
Fruit – piles, intestinal worms, urinary disorder, nose bleeding , phlegm, eye problem, diabetes, wounds and leprosy.
Twig – cough, asthma, piles, intestinal worms, spermatorrhoea, urinary disorders, diabetes.
Gum – ringworms,scabies, wounds and ulcers.
Seed pulp and oil- leprosy and intestinal worms.
Others
Young tender branches are chewed for toothbrushing use.
Leaf’s oil is used as a local antiseptic and insecticide.
Neem oil may be useful for gingivitis.
In the rural areas, burning of leaves and seeds used as mosquito repellant.
Neem oil has been shown to possess some spermicidal and contraceptive properties when used intravaginally.
Use of neem oil in animals showed lowering of glucose
Commercial use
Neem extracts used in the manufacture of toothpaste for its antibacterial properties.
Fresh seed oil has a strong garlic odor and is an ingredient for insect sprays.
Studies
• Studies have suggested hypoglycemic, antiulcer, antifertility, antimalarial, antifungal, antibacterial, antiviral, anticancer and antioxidant effects.
• Effect of essential oils from two Nigerian medicinal plants (Azadirachta indica and Morinda lucida) on growth and aflatoxin B1 production in maize grain by a toxigenic Aspergillus flavus: Oils from A indica completely suppressed aflatoxin synthesis.
• Lipid Effects / Antiviral: Effect of Supplemental Garlic and Neem Leaves in Broiler Feeds on Blood Cholesterol, Triglycerids and Antibody Titer: Study showed neem had greater potential than garlic in reducing cholesterol, triglycerides and increasing the antibody titers against viruses.
• Anti-ulcer: Mechanism of antiulcer effect of Neem (Azadirachta indica) leaf extract: effect on H+-K+-ATPase, oxidative damage and apoptosis: Study suggests antiulcer activity is achieved by blocking acid secretionn through inhibition of H+K+ATPase and preventing oxidative damage and apoptosis.
• Anti-candidal: Anticandidal activity of Azadirachta indica: Study suggested hexane and alcoholic extracts to have anticandidal potential.
Source: http://www.stuartxchange.org/Neem.html
Related Sites:
http://www.discoverneem.com/neem-benefits.html
http://www.articlealley.com/article_766808_17.html
http://herbal-properties.suite101.com/article.cfm/research_supports_value_of_neem_herbal_extracts
http://www.healthypages.co.uk/newsitem.php?news=6070
http://www.americanchronicle.com/articles/view/42953
http://www.goherbalremedies.com/blog/herbal-remedies-by-neem-leaves-margosa/
http://www.neemfoundation.org/neem-articles/neem-in-health.html